How does Endothelial Health correlate with Cardiovascular Health?

Vascular disease can begin even before the age of 20. As we age damage to the vessels from high blood pressure, plaque buildup, and inflammatory conditions show up as decreased elasticity from scarring and calcifications.

Evaluation of Cardiovascular Disease with Endo PAT

If you have 2 or more of these risk factors, discuss EndoPAT screening with your doctor.

· Heart Disease 

· High Blood Pressure 

· High Cholesterol 

· Diabetes  

· Overweight 

· History of smoking 

· Erectile Dysfunction 

· Immune Disorders (including autoimmune) 

· Endocrine Disorders 

· Family History of Heart Disease  

Why should you consider EndoPAT testing?

  • Evaluation of Endothelial Dysfunction whether early or late phase
  • Other more common invasive diagnostic tests don’t detect disease until it is advanced
  • Treatment progress can also be easily monitored
  • Testing is non-invasive and cheaper
  • The EndoPAT test has been FDA approved since 2003  

The purpose of the test is to access the health of your arteries by looking at blood flow through your arm.




What is EndoPAT?

The EndoPAT is the leading medical device for noninvasive endothelial function assessment. It was developed and is distributed by Itamar Medical, Caesarea, Israel.   

The PAT (Peripheral Arterial Tone) signal is a proprietary technology used for non-invasively measuring arterial tone changes in peripheral arterial beds. The PAT signal used in the EndoPAT is measured from the fingertip by recording finger arterial pulsatile volume changes. Results of the 15-minute test are automatically calculated and an EndoScore is generated, which indicates the present state of endothelial health. EndoPAT is the only FDA-cleared device indicated for assessment of Endothelial Function. Clearance was obtained by demonstrating equivalence of PAT Technology with an invasive catheterization procedure that directly assessed endothelial dysfunction in coronary arteries. The clinical research was conducted at the Mayo Clinic. 

How does the EndoPAT measure endothelial function?

EndoPAT quantifies the endothelium-mediated changes in vascular tone, elicited by a 5-minute occlusion of the brachial artery (using a standard blood pressure cuff). When the cuff is released, the surge of blood flow causes an endothelium-dependent. Flow Mediated Dilatation (FMD). The dilatation, manifested as Reactive Hyperemia, is captured by EndoPAT™ as an increase in the PAT Signal amplitude. A post-occlusion to pre-occlusion ratio is calculated by the EndoPAT software, providing the EndoPAT index.  

Why should I get tested with the EndoPAT?

Prevention is the best treatment! Cardiovascular disease develops over many years. Initially it is a silent process, often called subclinical atherosclerosis. Endothelial dysfunction is considered to be the hallmark of subclinical atherosclerosis and the earliest clinically detectable stage. Unlike atherosclerosis, endothelial dysfunction is reversible with proper treatment. 


How is endothelial dysfunction treated?

Endothelial dysfunction can be treated and reversed by many existing therapies such as lifestyle modification, homeopathic remedies (such as L-Arginine), drugs (e.g. statins to lower high cholesterol, ACE inhibitors used to treat high blood pressure, PDE5 inhibitor used to treat erectile dysfunction) and treatment of co-morbidities (e.g. glycemic control for diabetics). New agents that treat endothelial dysfunction specifically are under development. Endothelial dysfunction is treatable and even reversible. 



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